Mutationalprocessesof tobacco smokingand APOBECactivitygenerate protein-truncating mutations incancergenomes

Authors: Nina Adler, Alexander T. Bahcheli, Kevin C. L. Cheng, Khalid N. Al-Zahrani, Mykhaylo Slobodyanyuk, Diogo Pellegrina, Daniel Schramek, Jüri Reimand

Cancer is driven by a few mutations that enable oncogenic properties of cells; This study found that smoking commercial tobacco is associated with changes to DNA that make cancers harder to treat.

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https://www.science.org/doi/epdf/10.1126/sciadv.adh3083

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